Multiple sclerosis (MS) is the most common immune-mediated inflammatory demyelinating disease of the central nervous system. It causes vision problems, numbness and tingling, muscle weakness, and other problems(1).
Multiple sclerosis is typically treated with disease-modifying drugs, this approach substantially controls inflammatory activity, but not neurodegenerative processes, and does not cure the disease, so people with multiple sclerosis often experience residual symptoms and dysfunction(2).
Exercise training has increasingly been recommended for patients with multiple sclerosis to manage symptoms(3). Robot-assisted gait training is feasible and may be an effective therapeutic option in MS patients with severe walking disabilities(4). Virtual reality systems may strengthen the effect of robot-assisted gait training(5). In addition, aquatic therapy can improve the gait speed in patients with multiple sclerosis(6).